|
T6043 |
PF-3845
|
|
FAAH
,
Autophagy
|
|
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2. |
|
T7688 |
4-Nonylphenylboronic acid
|
|
FAAH
|
|
4-Nonylphenylboronic acid is a inhibitor of FAAH. |
|
T28353 |
PDP-EA
|
|
FAAH
|
|
PDP-EA is an activator of fatty acid amide hydrolase(FAAH) and enhances the amidohydrolase activity of FAAH. |
|
T2684 |
JNJ-1661010
|
JNJ1661010,Takeda-25,JNJ 1661010 |
FAAH
|
|
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2. |
|
T9967 |
MAGL-IN-5
|
|
Lipid
|
|
MAGL-IN-5 is a non-selective lipase inhibitor. |
|
T3215 |
JNJ-42165279
|
JNJ42165279 |
FAAH
,
Autophagy
|
|
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 re... |
|
T8646 |
URB937
|
|
FAAH
|
|
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM). |
|
T2338 |
JZL195
|
|
FAAH
,
Lipase
,
Autophagy
|
|
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor. |
|
T8927 |
WWL 154
|
WWL-154 |
FAAH
|
|
WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor. |
|
T4323 |
PF-04457845
|
PF04457845,PF 04457845 |
FAAH
,
Autophagy
|
|
PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM). |
|
T1325 |
Carprofen
|
Ridamyl,Imadyl,Rimadyl |
FAAH
,
COX
,
Autophagy
|
|
Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. |
|
T15802 |
LY2183240
|
|
FAAH
,
Autophagy
|
|
LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM). |
|
T3354 |
BIA 10-2474
|
BIA10-2474 |
FAAH
,
Autophagy
|
|
BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest o... |
|
T9374 |
AA38-3
|
1-Piperidinecarboxylic acid, 4-nitrophenyl ester |
FAAH
,
Lipase
,
MAGL
|
|
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH) |
|
T11256 |
FAAH inhibitor 1
|
Benzothiazole analog 3 |
FAAH
|
|
FAAH inhibitor 1 (Benzothiazole analog 3) is an effective FAAH inhibitor with an IC50 of 18 nM. |
|
T15268 |
FAAH-IN-2
|
O-Desmorpholinopropyl Gefitinib |
FAAH
,
Autophagy
|
|
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase). |
|
T6714 |
URB-597
|
KDS-4103,FAAH Inhibitor II |
Mitophagy
,
FAAH
,
Autophagy
|
|
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets. |
|
T27405 |
GAT211
|
GAT-211,AZ-4,GAT 211,AZ 4,AZ4 |
|
|
GAT211 is a CB1 positive allosteric modulator. GAT211 suppresses allodynia and produces synergistic antiallodynic effects with monoacylglycerol lipase and fatty acid amide hydrolase inhibitors in paclitaxel-treated mice. |
|
T28076 |
MM-433593
|
|
FAAH
|
|
MM-433593 is a selective fatty acid amide hydrolase (FAAH-1) inhibitor for the treatment of pain, inflammation, and other disorders. |
|
T15635 |
JZP-430
|
|
Lipase
,
MAGL
|
|
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL... |
|
T63536 |
Dual FAAH/sEH-IN-1
|
|
FAAH
,
Epoxide Hydrolase
|
|
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity. |
|
T68492 |
AM 374
|
HDSF,Hexadecanesulfonyl fluoride |
FAAH
|
|
AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease resear... |
|
T67896 |
CB2R/FAAH modulator-1
|
|
Cannabinoid Receptor
,
FAAH
|
|
CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and i... |
|
T26311 |
URB532
|
URB-532,FAAH Inhibitor I,FAAH Inhibitor-I,URB 532 |
|
|
URB532 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor. |
|
T12827 |
SA72
|
|
Others
|
|
SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH). |
|
T29045 |
UCM710
|
|
|
|
UCM710 is a dual inhibitor of α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH). |
|
T68407 |
URB-694
|
|
|
|
URB-694 is a fatty acid amide hydrolase (FAAH) inhibitor. |
|
T16847 |
SA 47
|
|
FAAH
|
|
SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate. |
|
T27681 |
JNJ-40355003
|
JNJ40355003 |
|
|
JNJ-40355003, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, elevates the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and c... |
|
T28059 |
MK-4409
|
MK4409,MK 4409 |
|
|
MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, is being investigated for the treatment of inflammatory and neuropathic pain. |
|
T11255 |
FAAH-IN-1
|
|
FAAH
|
|
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively. |
|
T71307 |
JNJ-40413269
|
|
|
|
JNJ-40413269 is a competitive inhibitor of fatty acid amide hydrolase (FAAH), which demonstrates robust central target engagement, and shows efficacious in a rat model of neuropathic pain. |
|
T40775 |
SSR411298
|
SSR411298 |
|
|
SSR411298 is a reversible, orally active compound that selectively inhibits fatty acid amide hydrolase (FAAH). Its potential lies in the field of post-traumatic stress disorder (PTSD) research. |
|
T28007 |
MDPD
|
|
|
|
MDPD is an enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis. MDPD alleviates the growth inhibitory effects of NAE 12:0, in part by enhancing the enzymatic activity of Arabid... |
|
T71995 |
Decanoyl chloride
|
|
|
|
Decanoyl Chloride is used in the synthesis of an effective metalloproteinase inhibitor. Also acts as a reagent in the synthesis of reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase as potnetial analge... |
|
T61380 |
Carpro-AM1
|
|
|
|
Carpro-AM1 is a compound that acts as a dual inhibitor of both fatty acid amide hydrolase (FAAH) and substrate-selective cyclooxygenase (COX). It exhibits potent inhibitory activity against FAAH, with an IC50 value of 94... |
|
T25918 |
Palmitoyl-L-aspartic acid
|
L-N-Palmitoylaspartic acid |
|
|
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec... |
|
T78593 |
JP104
|
|
FAAH
|
|
JP104 is an aryl carbamate that irreversibly inhibits fatty acid amide hydrolase (FAAH) with a pIC50 value of approximately 8 [1]. |
|
T33789 |
Oleoyl proline
|
N-Oleoyl-l-proline |
|
|
Oleoyl proline is an N-acyl amine that can be detected in bovine brain extracts and D. melanogaster larvae using mass spectrometry. In a preclinical model of pain, mice lacking fatty acid amide hydrolase (FAAH KO) had de... |
|
T61198 |
FAAH/MAGL-IN-1
|
|
|
|
FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, res... |
|
T37217 |
N-Decanoyl p-Nitroaniline
|
|
|
|
N-Decanoyl p-nitroaniline (DepNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a var... |
|
T78674 |
Isopropyl dodec-11-enylfluorophosphonate
|
IDEFP |
FAAH
|
|
Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibits equipotent inhibition of fatty acid amide hydrolase (FAAH), with b... |
|
T62558 |
FAAH-IN-5
|
|
|
|
FAAH-IN-5 (Compound 7) is a relatively selective, irreversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50: 10.5 nM). FAAH-IN-5 has low PAMPA (parallel artificial membrane permeability assay) permeability. |
|
T38143 |
Elaidamide
|
|
|
|
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu... |
|
T38223 |
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
|
|
|
|
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxis... |
|
T73302 |
FAAH-IN-7
|
|
|
|
FAAH-IN-7, a potent and reversible inhibitor of fatty acid amide hydrolase (FAAH), demonstrates significant neuroprotective effects, particularly by mitigating oxidative stress in 1321N1 astrocytes. With an IC50 value of... |
|
T38138 |
ACEA
|
2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide |
|
|
Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces ... |
|
T73317 |
JZP-MA-13
|
|
|
|
JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor, demonstrating impressive specificity with an IC50 value of 392 nM, and exhibits no inhibitory effects on monoacylglycerol lipase (MAGL), ABHD12, fatty ac... |
|
T62671 |
FAAH/MAGL-IN-3
|
|
|
|
FAAH/MAGL-IN-3 (Compound 10) is an irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) that acts on FAAH (IC50: 179 nM) and MAGL (IC50: 759 nM). FAAH/MAGL-IN-3 showed littl... |
|
T35786 |
O-7460
|
|
|
|
In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (... |
